The absorption of Paracetamol may be accelerated by metoclopramide. The excretion may be affected and plasma concentrations altered when administered with probenecid. Chlorpheniramine maleate may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics and anxiolytic sedatives. MAOIs may enhance the antimuscarinic effects of antihistamines. When sympathomimetics are given to patients receiving MAOIs, hypertensive reactions, including hypertensive crises may occur. The antihypertensive effects of methyldopa, mecamylamine, reserpine and veratrum alkaloids may be reduced by sympathomimetics. Beta-adrenergic-blocking agents may also interact with sympathomimetics. Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis. Antacids increase the rate of pseudoephedrine absorption; kaolin decreases it.
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